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Graphical contents list • MISCELLANEOUS PDF (450 K) | |||
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Bioorganic & Medicinal Chemistry Letters Symposia-in-Print • LITERATURE PDF (71 K) | |||
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Therapeutic intervention targeting protein–protein interactions • EDITORIAL Jean Chmielewski SummaryPlus | Full Text + Links | PDF (60 K) | |||
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Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein • SHORT COMMUNICATION Hang Yin and Andrew D. Hamilton SummaryPlus | Full Text + Links | PDF (397 K) | |||
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Fertilin peptidic liposomes inhibit fertilization by steric blockage • SHORT COMMUNICATIONSamidha Konkar , Suparna Gupta and Nicole S. Sampson SummaryPlus | Full Text + Links | PDF (180 K) | |||
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Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain • SHORT COMMUNICATION Tao Li , Dorina Saro and Mark R. Spaller SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Dual surface selection methodology for the identification of thrombin binding epitopes from hotspot biased phage-display libraries • SHORT COMMUNICATION Srivats Rajagopal , Roberto Meza-Romero and Indraneel Ghosh SummaryPlus | Full Text + Links | PDF (241 K) | |||
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Crucial amides for dimerization inhibitors of HIV-1 protease • SHORT COMMUNICATION Michael J. Bowman and Jean Chmielewski SummaryPlus | Full Text + Links | PDF (235 K) | |||
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Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: design of ICAM-1 cyclic peptides • SHORT COMMUNICATION Meagan E. Anderson , Tatyana Yakovleva , Yongbo Hu and Teruna J. Siahaan SummaryPlus | Full Text + Links | PDF (175 K) | |||
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Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins • SHORT COMMUNICATION Bin Yang , Dongxiang Liu and Ziwei Huang SummaryPlus | Full Text + Links | PDF (243 K) | |||
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Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor • SHORT COMMUNICATION Christopher Tan , Lianhu Wei , F. Peter Ottensmeyer ,Ira Goldfine , Betty A. Maddux , Cecil C. Yip , Robert A. Batey and Lakshmi P. Kotra SummaryPlus | Full Text + Links | PDF (223 K) | |||
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Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles • SHORT COMMUNICATION Allan Wissner , Philip R. Hamann , Ramaswamy Nilakantan , Lee M. Greenberger , Fei Ye , Timothy A. Rapuano and Frank Loganzo SummaryPlus | Full Text + Links | PDF (241 K) | |||
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Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity • SHORT COMMUNICATION Helen Y. Chen , Kevin D. Dykstra , Elizabeth T. Birzin , Katalin Frisch , Wanda Chan , Yi T. Yang , Ralph T. Mosley , Frank DiNinno , Susan P. Rohrer , James M. Schaeffer and Milton L. Hammond SummaryPlus | Full Text + Links | PDF (262 K) | |||
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The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria • SHORT COMMUNICATION Gary C. Look , Charles Vacin , Tracy M. Dias , Sun Ho , Thuy H. Tran , Laurance L. Lee , Cedric Wiesner , Flora Fang , Andrea Marra , Don Westmacott et al. SummaryPlus | Full Text + Links | PDF (183 K) | |||
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Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA–FtsZ interaction • SHORT COMMUNICATION Lee D. Jennings , Ken W. Foreman , Thomas S. Rush, III , Desiree H. H. Tsao , Lidia Mosyak , Yuanhong Li , Mohani N. Sukhdeo , Weidong Ding , Elizabeth G. Dushin et al. SummaryPlus | Full Text + Links | PDF (240 K) | |||
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Crucial role of the peroxyketal function for antimalarial activity in the G-factor series • SHORT COMMUNICATION Fadia Najjar , Liliane Gorrichon , Michel Baltas , Henri Vial , Théodore Tzedakis and Christiane André-Barrès SummaryPlus | Full Text + Links | PDF (168 K) | |||
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Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands • SHORT COMMUNICATION Christopher J. Arnusch , Sabine André , Paola Valentini , Martin Lensch , Roland Russwurm , Hans-Christian Siebert , Marcel J. E. Fischer , Hans-Joachim Gabius and Roland J. Pieters SummaryPlus | Full Text + Links | PDF (223 K) | |||
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Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization • SHORT COMMUNICATION Robert B. Perni , Janos Pitlik , Shawn D. Britt , John J. Court , Lawrence F. Courtney , David D. Deininger , Luc J. Farmer , Cynthia A. Gates , Scott L. Harbeson , Rhonda B. Levin et al. SummaryPlus | Full Text + Links | PDF (292 K) | |||
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HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors • SHORT COMMUNICATION Gabriela Iurcu Mustata , Alessandro Brigo and James M. Briggs SummaryPlus | Full Text + Links | PDF (368 K) | |||
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Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase- • SHORT COMMUNICATION Baoqing Gong , Feng Hong , Cory Kohm , Lynn Bonham and Peter Klein SummaryPlus | Full Text + Links | PDF (215 K) | |||
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Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid • SHORT COMMUNICATION Yong Xu , Yimin Fang , Jie Chen and Glenn D. Prestwich SummaryPlus | Full Text + Links | PDF (146 K) | |||
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Determination of the stable conformation of GABAA-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis • SHORT COMMUNICATION Dongmei Han , F. Holger Försterling , Xiaoyan Li , Jeffrey R. Deschamps , Hui Cao and James M. Cook SummaryPlus | Full Text + Links | PDF (272 K) | |||
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Synthesis of cinnamic acids and related isosteres as potent and selective  v3 receptor antagonists • SHORT COMMUNICATIONThomas D. Penning , Mark A. Russell , Barbara B. Chen , Helen Y. Chen , Bipin N. Desai , Stephen H. Docter , David J. Edwards , Glen J. Gesicki , Chi-Dean Liang , James W. Malecha et al. SummaryPlus | Full Text + Links | PDF (236 K) | |||
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Identification of novel potent bicyclic peptide deformylase inhibitors • SHORT COMMUNICATION Valentina Molteni , Xiaohui He , Juliet Nabakka , Kunyong Yang , Andreas Kreusch , Perry Gordon , Badry Bursulaya , Ian Warner , Tanya Shin , Tanya Biorac et al. SummaryPlus | Full Text + Links | PDF (239 K) | |||
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Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors • SHORT COMMUNICATION John Wityak , Frank W. Hobbs , Daniel S. Gardner , Joseph B. Santella, III , Joseph J. Petraitis , Jung-Hui Sun , Margaret F. Favata , Andrea J. Daulerio , Kurumi Y. Horiuchi et al. SummaryPlus | Full Text + Links | PDF (202 K) | |||
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New PDMP analogues inhibit process outgrowth in an insect cell line • SHORT COMMUNICATION Jacob P. Slavish , Donna K. Friel , Lynne A. Oland and Robin Polt SummaryPlus | Full Text + Links | PDF (303 K) | |||
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Aminomethylpyrimidines as novel DPP-IV inhibitors: A 105-fold activity increase by optimization of aromatic substituents • SHORT COMMUNICATION Jens-Uwe Peters , Silja Weber , Stéphane Kritter , Peter Weiss , Angelina Wallier , Markus Boehringer , Michael Hennig , Bernd Kuhn and Bernd-Michael Loeffler SummaryPlus | Full Text + Links | PDF (178 K) | |||
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2-(N-Acyl) and 2-N-acyl-N6-substituted analogues of adenosine and their affinity at the human adenosine receptors • SHORT COMMUNICATION Prakash G. Jagtap , Zhiyu Chen , Csaba Szabó and Karl-Norbert Klotz SummaryPlus | Full Text + Links | PDF (177 K) | |||
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Hypocrellin derivative with improvements of red absorption and active oxygen species generation • SHORT COMMUNICATION Shangjie Xu , Shen Chen , Manhua Zhang and Tao Shen SummaryPlus | Full Text + Links | PDF (129 K) | |||
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Structure–activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines • SHORT COMMUNICATION Hirobumi Takahashi , Norikazu Ohtake , Toshihiro Sakamoto , Tomoharu Iino , Nobuhiko Kawanishi , Masayuki Nakamura , Takashi Yoshizumi , Kenji Niiyama , Satoshi Ozaki , Hiromasa Okada et al. SummaryPlus | Full Text + Links | PDF (218 K) | |||
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Peroxidase catalyzed formation of azine pigments—a convenient and sensitive method for the identification of human cells with positive myeloperoxidase reactivity • SHORT COMMUNICATION Anja Bodtke , Wolf-Diethard Pfeiffer , Norbert Ahrens and Peter Langer SummaryPlus | Full Text + Links | PDF (173 K) | |||
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Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF--induced VCAM-1 expression • SHORT COMMUNICATION Charles Q. Meng , X. Sharon Zheng , Liming Ni , Zhihong Ye , Jacob E. Simpson , Kimberly J. Worsencroft , Martha R. Hotema , M. David Weingarten , Jason W. Skudlarek , Joshua M. Gilmore et al. SummaryPlus | Full Text + Links | PDF (193 K) | |||
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Synthesis of a novel nitroimidazole-spermidine derivative as a tumor-targeted hypoxia-selective cytotoxin • SHORT COMMUNICATION Maria V. Papadopoulou , Howard S. Rosenzweig and William D. Bloomer SummaryPlus | Full Text + Links | PDF (147 K) | |||
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Synthesis of novel 2-nitroimidazole-tethered tricyclic quinolines, bearing a second heteroatom, and their in vitro evaluation as hypoxia-selective cytotoxins and radiosensitizers • SHORT COMMUNICATION Maria V. Papadopoulou , Howard S. Rosenzweig and William D. Bloomer SummaryPlus | Full Text + Links | PDF (140 K) | |||
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KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine • SHORT COMMUNICATION Tooru Kimura , Daisuke Shuto , Soko Kasai , Ping Liu , Koushi Hidaka , Takashi Hamada , Yoshio Hayashi , Chinatsu Hattori , Masashi Asai , Shinobu Kitazume et al. SummaryPlus | Full Text + Links | PDF (278 K) | |||
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New potential calcium channel modulators: design and synthesis of compounds containing two pyridine, pyrimidine, pyridone, quinoline and acridine units under microwave irradiation • SHORT COMMUNICATION Shujiang Tu , Chunbao Miao , Fang Fang , Feng Youjian , Tuanjie Li , Qiya Zhuang , Xiaojing Zhang , Songlei Zhu and Daqing Shi SummaryPlus | Full Text + Links | PDF (161 K) | |||
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Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480 • SHORT COMMUNICATION Gianluca Sbardella , Antonello Mai , Marino Artico , Roberta Loddo , Maria Grazia Setzu and Paolo La Colla SummaryPlus | Full Text + Links | PDF (180 K) | |||
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A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor • SHORT COMMUNICATION Mickaël Montembault , Giang Vo-Thanh , Abdallah Deyine , Valérie Fargeas , Monique Villiéras , Ané Adjou , Didier Dubreuil , Didier Esquieu , Catherine Grégoire , Sandrine Opi et al. SummaryPlus | Full Text + Links | PDF (193 K) | |||
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A novel approach to the synthesis of cytotoxic C2–C3 unsaturated pyrrolo[2,1-c][ and ]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents • SHORT COMMUNICATION Zhizhi Chen , Stephen J. Gregson , Philip W. Howard and David E. Thurston SummaryPlus | Full Text + Links | PDF (158 K) | |||
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Synthesis and evaluation of a conformationally constrained pyridazinone PNA-monomer for recognition of thymine in triple-helix structures • SHORT COMMUNICATION Anne Goldbech Olsen , Otto Dahl and Peter E. Nielsen SummaryPlus | Full Text + Links | PDF (162 K) | |||
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Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2 • SHORT COMMUNICATION Peter Ettmayer , Andreas Billich , Thomas Baumruker , Diana Mechtcheriakova , Heide Schmid and Peter Nussbaumer SummaryPlus | Full Text + Links | PDF (186 K) | |||
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Metalated hybrid polymers as catalytic reagents for phosphate ester hydrolysis and plasmid modification • SHORT COMMUNICATION Vadapalli Chandrasekhar , Pravas Deria , Venkatasubbaiah Krishnan , Arunachalampillai Athimoolam , Sanjay Singh , C. Madhavaiah , S. G. Srivatsan and Sandeep Verma SummaryPlus | Full Text + Links | PDF (193 K) | |||
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Thrombin inhibitors built on an azaphenylalanine scaffold • SHORT COMMUNICATION Anamarija Zega , Gregor Mlin SummaryPlus | Full Text + Links | PDF (236 K) | |||
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Synthesis and biological activity of selective azasugar-based TACE inhibitors • SHORT COMMUNICATION Takahiro Tsukida , Hideki Moriyama , Yoshimasa Inoue , Hirosato Kondo , Kohichiro Yoshino and Shin-Ichiro Nishimura SummaryPlus | Full Text + Links | PDF (158 K) | |||
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(±)-cis-(6-Ethyl-tetrahydropyran-2-yl)-formic acid: a novel substance with antinociceptive properties • SHORT COMMUNICATION L. S. M. Miranda , Bruno G. Marinho , Suzana G. Leitão , Maria Eline Matheus , Patrícia D. Fernandes and M. L. A. A. Vasconcellos SummaryPlus | Full Text + Links | PDF (130 K) | |||
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Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction • SHORT COMMUNICATION Yingzhi Bi , Patrick Stoy , Leonard Adam , Bin He , John Krupinski , Diane Normandin , Ron Pongrac , Laurie Seliger , Andrew Watson and John E. Macor SummaryPlus | Full Text + Links | PDF (171 K) | |||
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Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents • SHORT COMMUNICATION Zhiyan Xiao , Shiqing Han , Kenneth F. Bastow and Kuo-Hsiung Lee SummaryPlus | Full Text + Links | PDF (193 K) | |||
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1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative • SHORT COMMUNICATION Yiming Li , Qian Li , Manchi Sun , Guoqiang Song , Shanhao Jiang and Dayuan Zhu SummaryPlus | Full Text + Links | PDF (151 K) | |||
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Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase • SHORT COMMUNICATION Keith G. Watson , Rachel Cameron , Rob J. Fenton , David Gower , Stephanie Hamilton , Betty Jin , Guy Y. Krippner , Angela Luttick , Darryl McConnell , Simon J. F. MacDonald et al. SummaryPlus | Full Text + Links | PDF (166 K) | |||
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Design, synthesis and structure–activity relationship of novel RXR-selective modulators • SHORT COMMUNICATION Pierre-Yves Michellys , Jennifer D'Arrigo , Timothy A. Grese , Donald S. Karanewsky , Mark D. Leibowitz , Dale A. Mais , Christopher M. Mapes , Anne Reifel-Miller , Deepa Rungta and Marcus F. Boehm SummaryPlus | Full Text + Links | PDF (255 K) | |||
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Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A • SHORT COMMUNICATION John T. Randolph , Daryl R. Sauer , Fortuna Haviv , Angela M. Nilius and Jonathan Greer SummaryPlus | Full Text + Links | PDF (150 K) | |||
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Editorial board • MISCELLANEOUS PDF (57 K) | |||
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Contributors to this issue • MISCELLANEOUS PDF (56 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (109 K) | |||
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